PXD054552-1

PXD054552 is an original dataset announced via ProteomeXchange.

Title	Traumatic Life Experiences During Critical Periods Lead to Diverse Developmental Trajectories
Description	Proper neurodevelopment relies on how life experiences influence the biology of an individual. This influence is pivotal during critical periods, which are time windows characterized by enhanced responsiveness to environmental stimuli. Positive experiences during these critical periods lead to healthy brain wiring and development of proper behavioral skills. Conversely, diverse traumatic events (e.g., physical/sexual abuse, prolonged hospitalization, warfare) can impair brain development, increasing risk for neuropsychiatric disorders. Whether a correspondence between specific traumas and the insurgence of certain neuropsychiatric traits exists remains elusive, suggesting that a particular traumatic event can trigger different psychiatric consequences. Here, we examined the long-term consequences of two different adverse life events (exposure to a predator scent or underwater immersion) in distinct developmental periods: infancy, childhood, adolescence, or young adulthood in wild type mice. We found specific alterations at both behavioral and molecular/cellular levels in adulthood in response to traumas experienced at different earlier developmental stages, suggesting a crucial role played by the timing (and not the type) of stress in shaping long-term effects. A parallel analysis in individuals exposed to traumatic life events revealed analogous results, highlighting the translational value of our findings. Finally, our data suggested BDNF pathway as a promising therapeutic target to ameliorate psychopathology related to trauma in early adulthood in mice and potentially also in individuals. Overall, our results point to the existence of critical periods for trauma exposure that differentially modulate the adult behavioral outcomes and induce time-specific molecular/cellular patterns in the brain, which may have therapeutic implications.
HostingRepository	PRIDE
AnnounceDate	2026-06-29
AnnouncementXML	Submission_2026-06-28_20:25:53.760.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Martina Bartolucci
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	acetylated residue; monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 480; Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2024-08-03 07:01:28	ID requested
⏵ 1	2026-06-28 20:25:54	announced

Morelli G, Visintin G, Gelli E, Serani A, Bartolucci M, Uccella S, D'Apruzzo M, Preiti D, Chellali MM, Cucinelli A, Rastogi M, Falappa M, Scalabrini A, Turecki G, Petretto A, Tucci V, Cancedda L, Traumatic life experiences during critical periods lead to diverse developmental trajectories. Cell Rep Med, 7(6):102798(2026) [pubmed]

10.1016/j.xcrm.2026.102798;

submitter keyword: brain,neurodevelopment, stress, traumatic event

Andrea Petretto
contact affiliation	IRCCS Istituto G Gaslini
contact email	a.petretto@gmail.com
lab head
Martina Bartolucci
contact affiliation	IRCCS Gaslini
contact email	smartibartolucci@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD054552

PRIDE project URI

• PRIDE
  1. PXD054552
     1. Label: PRIDE project
     2. Name: Traumatic Life Experiences During Critical Periods Lead to Diverse Developmental Trajectories