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PXD054502-1

PXD054502 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleAlterations in the nascent proteome during translation attenuation in response to mitochondrial stress induced by carbonyl cyanide m-chlorophenyl hydrazine (CCCP) and in response to EEF1A1 knockdown
DescriptionThis submission is a part of a proteomic resource consisting of four independent datasets and their meta-analysis which describe: the detailed landscape of changes in the nascent proteome at high temporal resolution with 30 min intervals upon rapid and reversible global translation attenuation in response to transient mitochondrial membrane depolarization and during the subsequent recovery of physiological translation upon the relief of this stress (PXD043942), comparison of nascent proteome alterations in response to two types of challenge to protein homeostasis – proteasome inhibition and mitochondrial inner membrane depolarization (this submission, datasets expII and expIV) and finally nascent proteome alterations happening after silencing of elongation factor EEF1A1 in untreated and stress conditions (this submission, dataset expIII).
HostingRepositoryPRIDE
AnnounceDate2024-10-02
AnnouncementXMLSubmission_2024-10-02_04:33:26.463.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterRemigiusz Serwa
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListacetylated residue; monohydroxylated residue
InstrumentQ Exactive HF-X
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-08-01 08:04:40ID requested
12024-10-02 04:33:26announced
22024-10-22 07:00:25announced2024-10-22: Updated project metadata.
Publication List
10.1016/J.CELREP.2024.114803;
Keyword List
submitter keyword: mitochondria, EEF1A1 elongation factor,mitochondrial stress, nascent proteome, CCCP
Contact List
Agnieszka Chacinska
contact affiliationIMol Polish Academy of Sciences, Warsaw, Poland
contact emaila.chacinska@imol.institute
lab head
Remigiusz Serwa
contact affiliationThe International Institute of Molecular Mechanisms and Machines, Polish Academy of Sciences
contact emailr.serwa@imol.edu.pl
dataset submitter
Full Dataset Link List
Dataset FTP location
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