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PXD054457-1

PXD054457 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleExploring Protein Post-Translational Modifications of Breast Cancer Cells Using a Novel Combinatorial Search Algorithm
DescriptionPost-translational modification of proteins plays an important role in cancer cell biology. Protein encoded by oncogenes may be activated by phosphorylation, products of tumour suppressors might be inactivated by phosphorylation or ubiquitination, which marks them for degradation; Chromatin binding proteins are often methylated and/or acetylated. These are just a few of the many hundreds of post-translational modifications discovered by years of painstaking experimentation and chemical analysis of purified proteins. In recent years, mass spectrometry-based proteomics emerged as the principal technique for identifying such modifications in samples from cultured cells and tumour tissue. Here we used a recently developed combinatorial search algorithm implemented in the MGVB toolset to identify novel modifications in samples from breast cancer cell lines. Our results provide a rich resource of coupled protein abundance and post-translational modification data seen in the context of an important biological function - the response of cells to interferon gamma treatment - which can serve as a starting point for future investigations to validate promising modifications and explore the utility of the underlying molecular mechanisms as potential diagnostic or therapeutic targets.
HostingRepositoryMassIVE
AnnounceDate2024-09-12
AnnouncementXMLSubmission_2024-09-12_09:21:05.484.xml
DigitalObjectIdentifier
ReviewLevelNon peer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterMetodi V. Metodiev
SpeciesList scientific name: Homo sapiens;
ModificationListunknown modification; GG
Instrumentinstrument model
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-07-31 10:43:46ID requested
12024-09-12 09:21:05announced
Publication List
no publication
Keyword List
submitter keyword: breast cancer, interferon gamma, PTM, methylation
Contact List
Metoodi V. Metodiev
contact affiliationUniversity of Essex
contact emailmmetod@essex.ac.uk
lab head
Metodi V. Metodiev
contact affiliationUniversity of Essex
contact emailmmetod@essex.ac.uk
dataset submitter
Full Dataset Link List
MassIVE dataset URI
Dataset FTP location
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