PXD054435 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Identification of targets of DBIC |
| Description | Pyroptosis is a type of lytic cell death executed by members of the gasdermin family. It has been demonstrated that induction of pyroptosis can effectively inhibit tumor growth, which implicates a new strategy for clinical tumor therapy, especially for those tumors (such as melanoma) that are insensitive or resistant to the induction of apoptosis.By means of a chemical compound DBIC, designed and identified by our group recently, to induce GSDMC-mediated pyroptosis in melanoma cells. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-11-21 |
| AnnouncementXML | Submission_2025-11-21_01:18:57.638.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Kejun Xu |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Bruker Daltonics timsTOF series |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-07-31 05:54:10 | ID requested | |
| ⏵ 1 | 2025-11-21 01:18:58 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Nuclear receptor Nur77 |
| Heme |
| Granzyme B |
| GSDMC |
| Pyroptosis |
Contact List
| Liu-zheng Wu |
|---|
| contact affiliation | State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen 361102, Fujian Province, P. R. China |
| contact email | 1562263643@qq.com |
| lab head | |
| Kejun Xu |
|---|
| contact affiliation | Xiamen University |
| contact email | 1329490903@qq.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/11/PXD054435 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD054435
- Label: PRIDE project
- Name: Identification of targets of DBIC
