PXD054412-1

PXD054412 is an original dataset announced via ProteomeXchange.

Title	A male Denisovan mandible from Pleistocene Taiwan
Description	Denisovans are an extinct hominin group defined by ancient genomes of Middle to Late Pleistocene fossils from southern Siberia. Although genomic evidence suggests their widespread distribution throughout eastern Asia and possibly Oceania, so far only a few fossils from the Altai and Tibet are confidently identified molecularly as Denisovan. We identified a hominin mandible (Penghu 1) from Taiwan (10,000 to 70,000 years ago or 130,000 to 190,000 years ago) as belonging to a male Denisovan by applying ancient protein analysis. We retrieved 4241 amino acid residues and identified two Denisovan-specific variants. The increased fossil sample of Denisovans demonstrates their wider distribution, including warm and humid regions, as well as their shared distinct robust dentognathic traits that markedly contrast with their sister group, Neanderthals.
HostingRepository	PRIDE
AnnounceDate	2025-04-09
AnnouncementXML	Submission_2025-04-08_21:13:02.324.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Takumi Tsutaya
SpeciesList	scientific name: Palaeoloxodon sp.; NCBI TaxID: 3064006; scientific name: Suidae; NCBI TaxID: 9821; scientific name: Homininae; NCBI TaxID: 207598;
ModificationList	4-hydroxy-L-proline; monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2024-07-30 16:47:55	ID requested
⏵ 1	2025-04-08 21:13:02	announced

10.1126/SCIENCE.ADS3888;

submitter keyword: enamel, dentin, bone, Penghu,palaeoproteomics, Denisovan, Taiwan, LC-MS/MS

Frido Welker
contact affiliation	Globe Institute, University of Copenhagen
contact email	frido.welker@sund.ku.dk
lab head
Takumi Tsutaya
contact affiliation	The Graduate University for Advanced Studies
contact email	tsuta16@gmail.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD054412
     1. Label: PRIDE project
     2. Name: A male Denisovan mandible from Pleistocene Taiwan