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PXD054389-1

PXD054389 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleEnhancing Uterine Receptivity for Embryo Implantation through Controlled Collagenase Intervention
DescriptionIneffective endometrial matrix remodeling, a key factor in infertility, impedes embryo implantation in the uterine wall. Our study reveals the cellular and molecular impact of human collagenase-1 administration in mouse uteri, demonstrating enhanced embryo implantation rates. Collagenase-1 promotes remodeling of the endometrial extracellular matrix (ECM), degrading collagen fibers and proteoglycans. This process releases matrix-bound bioactive factors, (e.g. VEGF, decorin), facilitating vascular permeability and angiogenesis. Collagenase-1 elevates embryo implantation regulators, including NK cell infiltration and the key cytokine LIF. Remarkably, uterine tissue maintains structural integrity despite reduced endometrial collagen fiber tension. In-utero collagenase-1 application rescues implantation in the heat stress and embryo transfer models, known for low implantation rates. Importantly, ex-vivo exposure of human uterine tissue to collagenase-1 induces collagen de-tensioning and VEGF release, mirroring remodeling observed in mice. Our research highlights collagenase potential to induce and orchestrate cellular and molecular processes enhancing uterine receptivity for effective embryo implantation. This innovative approach underscores ECM remodeling mechanisms critical for embryo implantation
HostingRepositoryPRIDE
AnnounceDate2024-08-13
AnnouncementXMLSubmission_2024-08-13_03:39:32.154.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD054389
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterIdan Adir
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListacetylated residue; monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-07-30 06:15:24ID requested
12024-08-13 03:39:32announced
22024-10-22 06:54:46announced2024-10-22: Updated project metadata.
Publication List
10.26508/LSA.202402656;
10.6019/PXD054389;
Keyword List
submitter keyword: embryo, implantation, matrix proteolysis, collagen remodeling, collagenase-1,ECM
Contact List
Irit Sagi
contact affiliationDepartment of Immunology and Regenerative Biology The Weizmann Institute of Science
contact emailirit.sagi@weizmann.ac.il
lab head
Idan Adir
contact affiliationThe Weizmann Institute for Science
contact emailidanadir@gmail.com
dataset submitter
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Dataset FTP location
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