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PXD054319-1

PXD054319 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitlePan-cancer and multi-omics analyses reveal the diagnostic and prognostic value of BAZ2B
DescriptionThe BAZ2B gene belongs to the bromodomain gene family. The proteins encoded by members of this gene family are important components of chromatin remodelling complexes and have a potential role in transcriptional activation. However, the biological significance of BAZ2B in pan-cancer is unknown. In this study, we comprehensively analysed the functional characteristics of BAZ2B in human cancers and its role in immune response using The Cancer Genome Atlas (TCGA), Gene Expression Album (GEO), Genotype-Tissue Expression (GTEx) databases, and tools such as TIMER 2.0 and cBioPortal, and found that BAZ2B is down-regulated in certain cancers, and its overexpression is associated with patients’ poor prognosis, such as bladder, breast and endometrial cancers. In addition, we demonstrated for the first time that BAZ2B was under-expressed in breast cancer cells and promoted proliferation, migration and apoptosis of breast cancer cells.
HostingRepositoryiProX
AnnounceDate2024-07-26
AnnouncementXMLSubmission_2024-07-28_23:11:30.076.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJimin Guo
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumenttimsTOF Pro
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-07-28 23:10:37ID requested
12024-07-28 23:11:30announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: BAZ2B, pan-cancer, prognosis, immune infiltration, enrichment analysis, BRCA
Contact List
Yan Liu
contact affiliationNorth China University of Science and Technology
contact emailliuysm@ncst.edu.cn
lab head
Jimin Guo
contact affiliationNorth China University of Science and Technology
contact emailg1595594565@163.com
dataset submitter
Full Dataset Link List
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