PXD054290-1

PXD054290 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Mouse bone marrow-derived macrophages (BMDMs) loaded with atherogenic LDL
Description	While aging is well established as an important risk factor for the development and progression of atherosclerosis, the underlying molecular mechanisms of this relationship remain poorly defined, and its role in atherosclerosis regression is unknown. We investigated the response of bone marrow-derived macrophages isolated from old and young mice to atherogenic aggregated LDL.
HostingRepository	PRIDE
AnnounceDate	2025-05-07
AnnouncementXML	Submission_2025-05-06_22:44:33.940.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD054290
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Sasha Singh
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 480

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-07-26 13:01:02	ID requested
⏵ 1	2025-05-06 22:44:34	announced

Publication List

Boucher DM, Robichaud S, Lorant V, Leon JS, Suliman I, Rasheed A, Susser LI, Emerton C, Geoffrion M, De Jong E, Bowdish DME, Aikawa M, Aikawa E, Singh SA, Rayner KJ, Ouimet M, Age-Related Impairments in Immune Cell Efferocytosis and Autophagy Hinder Atherosclerosis Regression. Arterioscler Thromb Vasc Biol, 45(4):481-495(2025) [pubmed]
10.6019/PXD054290;
10.1161/atvbaha.124.321662;

Boucher DM, Robichaud S, Lorant V, Leon JS, Suliman I, Rasheed A, Susser LI, Emerton C, Geoffrion M, De Jong E, Bowdish DME, Aikawa M, Aikawa E, Singh SA, Rayner KJ, Ouimet M, Age-Related Impairments in Immune Cell Efferocytosis and Autophagy Hinder Atherosclerosis Regression. Arterioscler Thromb Vasc Biol, 45(4):481-495(2025) [pubmed]

10.6019/PXD054290;

10.1161/atvbaha.124.321662;

Keyword List

submitter keyword: Atherosclerosis, Murine,Ageing, Primary Cells

submitter keyword: Atherosclerosis, Murine,Ageing, Primary Cells

Contact List

Mireille Ouimet
contact affiliation	University of Ottawa
contact email	Mireille.Ouimet@uottawa.ca
lab head
Sasha Singh
contact affiliation	Brigham and Women's Hospital, Harvard Medical School
contact email	sasingh@bwh.harvard.edu
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD054290
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD054290

PRIDE project URI

Repository Record List

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