PXD054289-1

PXD054289 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Advanced multimodal mass spectrometry imaging reveals functional differences of placental villous compartments at microscale resolution
Description	We advanced our previously developed Metabolome Informed Proteome Imaging (MIPI) workflow and demonstrated its application in bio-medical science to elucidate molecular processes at microscale resolution. To prove MIPI's ability to functionally reduce the heterogeneity and complexity of human tissue, we utilized a full-term placenta from an obese person. Lipidomic and metabolomic imaging by MALDI-MSI visualized molecular composition and dynamic activities across the tissue sections, mapping placental villous regions with enriched metabolic activity related to sterol lipids and fatty acid processing. Our complementary proteome profiling of mapped regions allowed us to capture region-specific enzymes. Integration of the data from our multimodal MS-based approaches reconstructed underlying biological pathways relevant to placental function across histologically distinct villi regions.
HostingRepository	MassIVE
AnnounceDate	2025-01-16
AnnouncementXML	Submission_2025-01-16_10:39:29.022.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Matthew Monroe
SpeciesList	scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationList	Oxidation; Carbamidomethyl
Instrument	Orbitrap Exploris 240

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-07-26 13:00:00	ID requested
⏵ 1	2025-01-16 10:39:29	announced

Publication List

no publication

no publication

Keyword List

submitter keyword: MIPI, placenta

submitter keyword: MIPI, placenta

Contact List

Kristin Burnum-Johnson
contact affiliation	Pacific Northwest National Laboratory
contact email	Kristin.Burnum-Johnson@pnnl.gov
lab head
Matthew Monroe
contact affiliation	Pacific Northwest National Laboratory
contact email	matthew.monroe@pnnl.gov
dataset submitter

Full Dataset Link List

MassIVE dataset URI
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/v08/MSV000095456/

MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/v08/MSV000095456/