PXD054266-1

PXD054266 is an original dataset announced via ProteomeXchange.

Title	Proteomic Characterisation of Heart Failure Reveals Unique Molecular Phenotype for Hypertrophic Cardiomyopathy
Description	Hypertrophic cardiomyopathy (HCM) is a disease, which is difficult to diagnose at an early stage and for which there is a pressing need for more effective treatment options. The purpose of this study was to compare the molecular profile of HCM to that of ISCM and DCM for identification of protein and pathway targets that could support development of better diagnostic and treatment options for HCM. A high throughput mass spectrometry workflow was applied to achieve deep quantitative coverage of left ventricular tissue from HCM, DCM, ISCM and non-heart failure control patients. HCM had a diverse proteomic profile compared to that of DCM and ISCM. Dif-ferentially expressed proteins unique to HCM were identified based on an observed fold change of ≥ 1.5 or ≤-1.5 and q-value ≤ 0.005. Candidate proteins of interest were found to be significantly associated with clinical features of HCM. The significant association between these proteins and HCM was validated in an independent dataset. This represents one of the largest and deepest proteomic datasets for myocardial tissue reported to date. The dataset highlights the diverse proteomic profile of HCM, relative to other cardiomyopathies, and reveals disease-relevant pathways and promising biomarker candidates that are uniquely associated with HCM.
HostingRepository	PRIDE
AnnounceDate	2024-08-08
AnnouncementXML	Submission_2024-08-08_05:22:54.058.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ben Collins
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2024-07-26 02:16:20	ID requested
⏵ 1	2024-08-08 05:22:54	announced
2	2024-10-22 06:53:10	announced	2024-10-22: Updated project metadata.

10.3390/BIOMEDICINES12081712;

submitter keyword: ypertrophic cardiomyopathy, DIA, diaPASEF, biomarkers

Ben Collins
contact affiliation	Queen's University Belfast
contact email	ben.collins@qub.ac.uik
lab head
Ben Collins
contact affiliation	Queen's University Belfast
contact email	ben.collins@qub.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/08/PXD054266

PRIDE project URI

• PRIDE
  1. PXD054266
     1. Label: PRIDE project
     2. Name: Proteomic Characterisation of Heart Failure Reveals Unique Molecular Phenotype for Hypertrophic Cardiomyopathy