PXD054244 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomic characterization of the medial prefrontal cortex in chronic restraint stress mice |
Description | In this study, we used chronic restraint stress to establish a mouse model of depression, and differentially expressed proteins in the medial prefrontal cortex of depressive model mice were detected by TMT proteomics. By functional enrichment analysis of the differentially expressed proteins, we found that CRS-induced mice have altered synaptic function and excessive autophagy. In addition, we also demonstrated that CRS may disrupt synaptic plasticity by affecting activation of the Wnt2b/尾-catenin pathway which may help explain the pathogenesis of depression and identify new antidepressant drug targets. |
HostingRepository | PRIDE |
AnnounceDate | 2024-08-27 |
AnnouncementXML | Submission_2024-08-27_08:12:26.136.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Minghui Zhang |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | deamidated residue |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2024-07-25 10:23:50 | ID requested | |
⏵ 1 | 2024-08-27 08:12:26 | announced | |
Publication List
10.1016/j.jprot.2024.105278; |
Fu Y, Gu Z, Cao H, Zuo C, Huang Y, Song Y, Miao J, Jiang Y, Wang F, Proteomic characterization of the medial prefrontal cortex in chronic restraint stress mice. J Proteomics, 307():105278(2024) [pubmed] |
Keyword List
submitter keyword: Depression |
Proteomic |
Synaptic plasticity |
Autophagy |
Contact List
Wang Furong |
contact affiliation | Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No.1095 Jiefang Road, Wuhan, 430030, Hubei, China. |
contact email | wangfurong.china@163.com |
lab head | |
Minghui Zhang |
contact affiliation | Shandong University |
contact email | zhangmh9908@163.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/08/PXD054244 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD054244
- Label: PRIDE project
- Name: Proteomic characterization of the medial prefrontal cortex in chronic restraint stress mice