PXD054244-1

PXD054244 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Proteomic characterization of the medial prefrontal cortex in chronic restraint stress mice
Description	In this study, we used chronic restraint stress to establish a mouse model of depression, and differentially expressed proteins in the medial prefrontal cortex of depressive model mice were detected by TMT proteomics. By functional enrichment analysis of the differentially expressed proteins, we found that CRS-induced mice have altered synaptic function and excessive autophagy. In addition, we also demonstrated that CRS may disrupt synaptic plasticity by affecting activation of the Wnt2b/尾-catenin pathway which may help explain the pathogenesis of depression and identify new antidepressant drug targets.
HostingRepository	PRIDE
AnnounceDate	2024-08-27
AnnouncementXML	Submission_2024-08-27_08:12:26.136.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Minghui Zhang
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	deamidated residue
Instrument	Orbitrap Fusion Lumos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-07-25 10:23:50	ID requested
⏵ 1	2024-08-27 08:12:26	announced

Publication List

10.1016/j.jprot.2024.105278;
Fu Y, Gu Z, Cao H, Zuo C, Huang Y, Song Y, Miao J, Jiang Y, Wang F, Proteomic characterization of the medial prefrontal cortex in chronic restraint stress mice. J Proteomics, 307():105278(2024) [pubmed]

10.1016/j.jprot.2024.105278;

Fu Y, Gu Z, Cao H, Zuo C, Huang Y, Song Y, Miao J, Jiang Y, Wang F, Proteomic characterization of the medial prefrontal cortex in chronic restraint stress mice. J Proteomics, 307():105278(2024) [pubmed]

Keyword List

submitter keyword: Depression
Proteomic
Synaptic plasticity
Autophagy

submitter keyword: Depression

Proteomic

Synaptic plasticity

Autophagy

Contact List

Wang Furong
contact affiliation	Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No.1095 Jiefang Road, Wuhan, 430030, Hubei, China.
contact email	wangfurong.china@163.com
lab head
Minghui Zhang
contact affiliation	Shandong University
contact email	zhangmh9908@163.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/08/PXD054244
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/08/PXD054244

PRIDE project URI

Repository Record List

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