PXD054232-1

PXD054232 is an original dataset announced via ProteomeXchange.

Title	Proteomic analysis of small extracellular vesicles derived from human iPSC-MSCs
Description	Human mesenchymal stem cell-derived small extracellular vesicles(MSC-sEVs) have exhibited immunomodulatory and pro-regenerative properties. However, the absence of quantifiable and specific markers for defining and qualifying human MSC-sEVs impedes their translation into clinical practice. Here, we ranked the relative abundances of proteins representing unique signature for MSCs in the proteomic datasets of MSC-sEVs and chose several proteins with high relative abundances as candidate markers for MSC-sEVs. This work would facilitate the establishment of quantifiable, reproducible and standardized assays for defining MSC-sEV preparations, ultimately accelerating the translation of MSC-sEVs into clinical practice.
HostingRepository	iProX
AnnounceDate	2024-07-25
AnnouncementXML	Submission_2025-06-29_21:10:21.089.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Lei Luo
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2024-07-25 05:49:54	ID requested
⏵ 1	2025-06-29 21:10:21	announced

Dataset with its publication pending

submitter keyword: Proteomic analysis,Small extracellular vesicles,MSCs

Yang Wang
contact affiliation	Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
contact email	wangyang63@sjtu.edu.cn
lab head
Lei Luo
contact affiliation	Shanghai Jiao Tong University
contact email	97luolei@sjtu.edu.cn
dataset submitter

iProX dataset URI