PXD054188-1

PXD054188 is an original dataset announced via ProteomeXchange.

Title	The PDCD4-bound transcriptome uncovers novel targets for the tumour suppressor in non-malignant breast epithelial cells
Description	Programmed cell death protein 4 (PDCD4) is a well-known tumour suppressor and inhibitor of mRNA translation. Interestingly, the protein can play this inhibitory role only when localised in the cytoplasm, yet in most unstressed cells as well as cells derived from healthy tissues, PDCD4 resides almost exclusively within the nucleus. Its nuclear function remains unclear. Here we present a comprehensive investigation of all proteins and RNA interacting with the tumour suppressor in a non-tumorigenic epithelial cell line.
HostingRepository	PRIDE
AnnounceDate	2024-07-31
AnnouncementXML	Submission_2024-07-31_03:07:31.200.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sandip Kumar Patel
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2024-07-24 11:21:39	ID requested
⏵ 1	2024-07-31 03:07:31	announced

Dataset with its publication pending

submitter keyword: RNA-binding,PDCD4, nucleus, cell adhesion, translation control

Anne Willis
contact affiliation	MRC Toxicology Unit, University of Cambridge
contact email	tls36@cam.ac.uk
lab head
Sandip Kumar Patel
contact affiliation	Proteomics Core Facility, MRC Toxicology Unit, University of Cambridge
contact email	proteomics@mrc-tox.cam.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/07/PXD054188

PRIDE project URI

• PRIDE
  1. PXD054188
     1. Label: PRIDE project
     2. Name: The PDCD4-bound transcriptome uncovers novel targets for the tumour suppressor in non-malignant breast epithelial cells