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PXD054186-1
PXD054186 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | The changes in cetuximab resistant HNSCC cell lines (e.g., OECM1-cetuximabR and CAL-27 cetuximabR) after being treated with Cetuximab (500 ug/ml) for at least 2 months. We used LC-MS/MS to identify the main phosphorylation sites in resistance cell lines. |
| Description | Recent clinical trials revealed that prior use of Cetuximab may interfere with ICB efficacy. In this study, STAT1 protein levels changed after continued Cetuximab treatment (500 ug/ml). We used LC-MS/MS to compare the phosphorylation sites in wild-type and resistant cells. We proposed that the phosphorylation of STAT1 may lead to the degradation of the STAT1 protein. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-12-29 |
| AnnouncementXML | Submission_2025-12-28_16:05:06.963.xml |
| DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD054186 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Po-Hsien Chiu |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | phosphorylated residue; acetylated residue; iodoacetamide derivatized residue |
| Instrument | LTQ Orbitrap Elite |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-07-24 09:33:42 | ID requested | |
| ⏵ 1 | 2025-12-28 16:05:08 | announced |
Publication List
| 10.1016/j.xcrm.2025.102448; |
| Chiu PH, Lai KC, Wang HL, Chang YW, Wu WC, Chen TH, Tsai YS, Song JH, Sun NY, Chau GY, Fang WL, Chen JP, Wang HM, Huang HC, Hsieh MC, Hua CH, Lien MY, Chang YF, Wang HC, Chien CY, Huang TL, Wang CC, Liu YC, Chen JP, Lu WC, Yiu CY, Lin CL, Lou PJ, Chu PY, Wang SC, Hung MC, Yang MH, Therapeutic stress triggers tumor STAT1 acetylation to disarm immunotherapy. Cell Rep Med, 6(11):102448(2025) [pubmed] |
| 10.6019/PXD054186; |
Keyword List
| submitter keyword: Human, LC-MSMS, HNSCC, Cetuximab resistance, Phosphorylation |
Contact List
| Muh-Hwa Yang | |
|---|---|
| contact affiliation | Institute of Clinical Medicine in National Yang-Ming Chiao Tung University, Taiwan (Muh-Hwa Yang Lab) |
| contact email | mhyang2@nycu.edu.tw |
| lab head | |
| Po-Hsien Chiu | |
| contact affiliation | National Yang Ming Chiao Tung University |
| contact email | ck901396@gmail.com |
| dataset submitter | |
Full Dataset Link List
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| PRIDE project URI |
Repository Record List
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