PXD054158-1

PXD054158 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	ThermoTargetMiner: Proteome Integral Solubility Alteration (PISA) target database for prospective lung cancer drug candidates
Description	Knowledge of the targets of therapeutic compounds helps understanding the compound action mechanism as well as the side-effects. The multiple complementary techniques needed for comprehensive target characterization must combine data reliability with sufficient analysis throughput. Here, we test the Proteome Integral Solubility Alteration (PISA) assay by target identification of 67 approved anticancer drugs and candidates against pulmonary carcinoma.
HostingRepository	PRIDE
AnnounceDate	2026-06-10
AnnouncementXML	Submission_2026-06-09_21:00:16.940.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Hezheng Lyu
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos; Orbitrap Fusion

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-07-23 17:45:56	ID requested
⏵ 1	2026-06-09 21:00:17	announced

Publication List

Lyu H, Gharibi H, Meng Z, Sokolova B, Lundstr, ö, m S, Zhang X, Zubarev RA, Peptide-to-Protein Data Aggregation Using Fisher's Method Improves Target Identification in Chemical Proteomics. Anal Chem, 98(17):12596-12602(2026) [pubmed]
10.1021/acs.analchem.5c08021;

Lyu H, Gharibi H, Meng Z, Sokolova B, Lundstr, ö, m S, Zhang X, Zubarev RA, Peptide-to-Protein Data Aggregation Using Fisher's Method Improves Target Identification in Chemical Proteomics. Anal Chem, 98(17):12596-12602(2026) [pubmed]

10.1021/acs.analchem.5c08021;

Keyword List

submitter keyword: Human, proteomics, LC-MS, lung cancer

submitter keyword: Human, proteomics, LC-MS, lung cancer

Contact List

Roman Zubarev
contact affiliation	Division of Physiological Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 65 Stockholm, Sweden
contact email	roman.zubarev@ki.se
lab head
Hezheng Lyu
contact affiliation	Karolinska Institutet
contact email	hezheng.lyu@ki.se
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD054158
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD054158

PRIDE project URI

Repository Record List

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