PXD054146-1

PXD054146 is an original dataset announced via ProteomeXchange.

Title	NOTCH1 and Endothelial Mitochondrial Metabolism
Description	Notch signaling activation drives endothelial-to-mesenchymal transition (EndMT), which is key to heart development. Accumulating evidence indicates that endothelial cell metabolism reprogramming regulates endothelial function independent of canonical cell signaling. Herein, we investigated whether and how Notch signaling and metabolism reprogramming crosstalk in the EndMT process. We found Notch1 intracellular domain (NICD1) was localized within the mitochondria of endothelial cells and interacted with the PDH E1 subunit beta, influencing the phosphorylation of the PDH E1 subunit alpha, thereby activating PDH and enhancing mitochondrial metabolism.
HostingRepository	PRIDE
AnnounceDate	2025-01-18
AnnouncementXML	Submission_2025-01-17_19:50:10.580.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jie Wang
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2024-07-23 09:17:24	ID requested
⏵ 1	2025-01-17 19:50:11	announced

10.1038/s41467-024-54407-7;

Wang J, Zhao R, Xu S, Zhou XY, Cai K, Chen YL, Zhou ZY, Sun X, Shi Y, Wang F, Gui YH, Tao H, Zhao JY, NOTCH1 mitochondria localization during heart development promotes mitochondrial metabolism and the endothelial-to-mesenchymal transition in mice. Nat Commun, 15(1):9945(2024) [pubmed]

submitter keyword: NOTCH1 NICD1 PDC PDHB

Jian-Yuan Zhao
contact affiliation	Shanghai Jiao Tong University School of Medicine
contact email	zhaojy@vip.163.com
lab head
Jie Wang
contact affiliation	Children's Hospital of Fudan University
contact email	iris_wangjie@hotmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/01/PXD054146

PRIDE project URI

• PRIDE
  1. PXD054146
     1. Label: PRIDE project
     2. Name: NOTCH1 and Endothelial Mitochondrial Metabolism