PXD054140-1

PXD054140 is an original dataset announced via ProteomeXchange.

Title	Nucleosomes gate cofactor access to the transcription factor p53 P53-pos8-NCP
Description	In solution crosslinking mass spectrometry of transcription factor p53 with the members of the ubiquitin proteasome system (UPS) on chromatin.
HostingRepository	PRIDE
AnnounceDate	2025-07-31
AnnouncementXML	Submission_2025-07-31_06:59:41.115.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jan Seebacher
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	crosslinked residues with loss of water; crosslinked residues; phosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2024-07-23 04:17:57	ID requested
⏵ 1	2025-07-31 06:59:41	announced

Chakraborty D, Sandate CR, Isbel L, Kempf G, Weiss J, Cavadini S, Kater L, Seebacher J, Kozicka Z, Stoos L, Grand RS, Sch, ü, beler D, Michael AK, Thom, ä NH, Nucleosomes specify co-factor access to p53. Mol Cell, 85(15):2919-2936.e12(2025) [pubmed]

10.1016/j.molcel.2025.06.027;

submitter keyword: Proteome Discoverer, transcription factor, xlinkx, DSSO,Nucleosomes, ubiquitin proteasome system, XL-MS, cofactors, crosslinking

Nicolas Thoma
contact affiliation	Friedrich Miescher Institute for Biomedical Research, FMI, Switzerland
contact email	Nicolas.Thoma@fmi.ch
lab head
Jan Seebacher
contact affiliation	FMI Basel
contact email	jan.seebacher@fmi.ch
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/07/PXD054140

PRIDE project URI

• PRIDE
  1. PXD054140
     1. Label: PRIDE project
     2. Name: Nucleosomes gate cofactor access to the transcription factor p53 P53-pos8-NCP