PXD054113-1

PXD054113 is an original dataset announced via ProteomeXchange.

Title	The changes in HNSCC cell lines (e.g., OECM1) when treated with Cetuximab (500 ug/ml) at different passages. We used LC-MS/MS to identify the main target pathway. These findings could significantly enhance our evidence.
Description	Recent clinical trials revealed that prior use of Cetuximab may interfere with ICB efficacy. In this study, STAT1 protein levels changed after continued Cetuximab treatment (500 ug/ml). We collected serial passages of cetuximab resistance HNSCC cell lines to perform LC-MS/MS. We identified the IFN pathway as the key target to cause this effect.
HostingRepository	PRIDE
AnnounceDate	2025-12-29
AnnouncementXML	Submission_2025-12-28_16:09:23.233.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD054113
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Po-Hsien Chiu
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2024-07-22 06:18:03	ID requested
⏵ 1	2025-12-28 16:09:24	announced

10.1016/j.xcrm.2025.102448;

Chiu PH, Lai KC, Wang HL, Chang YW, Wu WC, Chen TH, Tsai YS, Song JH, Sun NY, Chau GY, Fang WL, Chen JP, Wang HM, Huang HC, Hsieh MC, Hua CH, Lien MY, Chang YF, Wang HC, Chien CY, Huang TL, Wang CC, Liu YC, Chen JP, Lu WC, Yiu CY, Lin CL, Lou PJ, Chu PY, Wang SC, Hung MC, Yang MH, Therapeutic stress triggers tumor STAT1 acetylation to disarm immunotherapy. Cell Rep Med, 6(11):102448(2025) [pubmed]

10.6019/PXD054113;

submitter keyword: Human, LC-MSMS, HNSCC, Cetuximab

Muh-Hwa Yang
contact affiliation	Institute of Clinical Medicine in National Yang-Ming Chiao Tung University, Taiwan (Muh-Hwa Yang Lab)
contact email	mhyang2@nycu.edu.tw
lab head
Po-Hsien Chiu
contact affiliation	National Yang Ming Chiao Tung University
contact email	ck901396@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/12/PXD054113

PRIDE project URI

• PRIDE
  1. PXD054113
     1. Label: PRIDE project
     2. Name: The changes in HNSCC cell lines (e.g., OECM1) when treated with Cetuximab (500 ug/ml) at different passages. We used LC-MS/MS to identify the main target pathway. These findings could significantly enhance our evidence.