PXD054045-1

PXD054045 is an original dataset announced via ProteomeXchange.

Title	Angiotensin I and II in Human Plasma and Serum and Mouse Plasma
Description	Fast turn around monitoring of Angiotensin I and II in blood. Plasma and Serum samples were digested with an HTA Protease in 20 minutes, spiked with SIL Angiotensin I and II and analyzed by targeted LC-MS. This preliminary data demonstrates that Angiotensin I and II can be rapidly measured and multiplexed with several proteins using the methodology. This methodology allows an unprecedent ability to monitor circulating biomarkers in almost real-time.
HostingRepository	PanoramaPublic
AnnounceDate	2025-10-31
AnnouncementXML	Submission_2025-10-31_17:12:23.415.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Simion Kreimer
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090; scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	Label:13C(6)15N(1); Label:13C(5)15N(1); Label:13C(9)15N(1); Label:13C(6)15N(4); Label:13C(2)15N(1); Label:13C(3)15N(1)
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2024-07-18 11:09:12	ID requested
⏵ 1	2025-10-31 17:12:23	announced

Yannone SM, Tuteja V, Goleva O, Leung DYM, Stotland A, Keoseyan AJ, Hendricks NG, Van Eyk JE, Kreimer S. Blood to Biomarker Quantitation in Under One Hour with Rapid Proteomics using a Hyperthermoacidic Protease. bioRxiv [Preprint]. 2024 Jun 2:2024.06.01.596979. doi: 10.1101/2024.06.01.596979. PMID: 38853916

PMCID: PMC11160709.

submitter keyword: HTA Protease, Krakatoa, Hyperthermoacidic Protease, Angiotensin, RAAS, Rapid Proteomics, Dual Trap Single Column, DTSC

Simion Kreimer
contact affiliation	Cedars-Sinai
contact email	simion.kreimer@cshs.org
lab head
Simion Kreimer
contact affiliation	Cedars-Sinai
contact email	simion.kreimer@cshs.org
dataset submitter

Panorama Public dataset URI