PXD054040 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | The Valine-Arginine dipeptide repeat protein encoded by mammalian telomeric RNA appears highly expressed in mitosis and may repress global translation |
| Description | Translation of mammalian telomeric G-rich RNA via the Repeat Associated non-AUG translation mechanism can produce two dipeptide repeat proteins: repeating valine-arginine (VR) and repeating glycine-leucine (GL). Their potentially toxic nature suggests that to be retained through evolution, one or both must play an important role in cells. Immunofluorescence staining revealed VR is in high abundance during mitosis and co-localizes with ribosomes and is highly abundant in the ventricular zone of the mouse cerebral cortex. To better understand the roles of VR, we sought to identify VR protein binding partners, we used affinity purification-mass spectrometry. Gene ontology enrichment analysis of VR binding partners revealed significant enrichment of ribosomal, mitotic, mRNA processing and DNA repair terms. Together, these data suggest a role for the VR dipeptide in mitotic progression and potentially in mRNA processing and translation. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-05-25 |
| AnnouncementXML | Submission_2026-05-24_16:18:22.758.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Christine Mills |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | monohydroxylated residue |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-07-18 08:13:34 | ID requested | |
| ⏵ 1 | 2026-05-24 16:18:23 | announced | |
Publication List
| 10.1073/pnas.2520441122; |
| Al-Turki T, Mantri V, Willcox S, Mills CA, Herring LE, Cho SJ, Lee H, Meyer C, Anton ES, Griffith JD, The telomeric valine-arginine dipeptide repeat protein changes state to diffuse staining in mitosis and represses in vitro translation. Proc Natl Acad Sci U S A, 122(47):e2520441122(2025) [pubmed] |
Keyword List
| submitter keyword: RNA binding, mitosis, translation.,VR dipeptide |
Contact List
| Jack D. Griffith |
|---|
| contact affiliation | Department of Microbiology and Immunology, Department of Biochemistry and Biophysics, and Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill |
| contact email | jdg@med.unc.edu |
| lab head | |
| Christine Mills |
|---|
| contact affiliation | University of North Carolina - Chapel Hill |
| contact email | allie.mills@unc.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD054040 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD054040
- Label: PRIDE project
- Name: The Valine-Arginine dipeptide repeat protein encoded by mammalian telomeric RNA appears highly expressed in mitosis and may repress global translation
