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PXD053997-1

PXD053997 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Anti-Toxoplasma gondii effect of vorinostat in vitro and in vivo
Description	Toxoplasma gondii is an important pathogenic protozoon that infects up to one-third of the world's population. In immunocompetent individuals, the infection generally is asymptomatic. However, in immunocompromised patients, the infection can lead to severe and fatal complications. This is due to the conversion of bradyzoites to tachyzoites as a result of reduced immune pressure. Therefore, it is necessary to discover drugs that have anti-Toxoplasma effect while simultaneously being effective against cancer.Our findings suggest that vorinostat demonstrates potency against T. gondii both in vitro and in vivo, which offers promise for treatment of human toxoplasmosis in cancer patients.
HostingRepository	iProX
AnnounceDate	2024-07-17
AnnouncementXML	Submission_2024-07-17_00:34:37.379.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Chunxue Zhou
SpeciesList	scientific name: Toxoplasma gondii RH-88; NCBI TaxID: 1208370;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Astral

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-07-17 00:32:23	ID requested
⏵ 1	2024-07-17 00:34:37	announced

Publication List

Dataset with its publication pending

Keyword List

submitter keyword: Toxoplasma gondii

Contact List

Chunxue Zhou
contact affiliation	Shandong University
contact email	zhouchunxue23@163.com
lab head
Chunxue Zhou
contact affiliation	Shandong University
contact email	zhouchunxue23@163.com
dataset submitter

Full Dataset Link List

iProX dataset URI