PXD053987-1

PXD053987 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Proteomic analysis of two leukemia cell lines K562 and Lucena-1.
Description	The Lucena 1 cell line, derived from the K562 human chronic myeloid leukemia cell line, shows multidrug resistance (MDR) due to selective pressure from vincristine supplementation. A proteomic analysis comparing K562 and Lucena 1 revealed qualitative differences. The ATP-dependent efflux pump, Translocase ABCB1, which is crucial for drug resistance, was a focus. Tubulin analysis identified an exclusive isoform, Tubulin beta 8B, in Lucena 1, potentially affecting resistance mechanisms. Additionally, Rap1A and Krit1 association in cytoskeletal regulation, along with STAT1 presence linked to urea cycle and tumor development, shed light on Lucena 1's unique biology. Increased Carbonic anhydrase I expression suggested a role in pH regulation. COP9, a tumor suppressor targeting p53, was discovered, further highlighting Lucena 1's complex molecular landscape. This study provides insights into the MDR phenotype and its multifactorial consequences in cellular pathways.
HostingRepository	jPOST
AnnounceDate	2024-08-13
AnnouncementXML	Submission_2024-08-12_11:29:10.314.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Emidio Beraldo Neto
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	S-carboxamidomethyl-L-cysteine; L-methionine sulfoxide
Instrument	instrument

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-07-16 10:18:33	ID requested
⏵ 1	2024-08-12 11:29:10	announced

Publication List

Dataset with its publication pending

Dataset with its publication pending

Keyword List

submitter keyword: K562, Lucena-1, leukemia, MDR

submitter keyword: K562, Lucena-1, leukemia, MDR

Contact List

Emidio Beraldo Neto
lab head
Emidio Beraldo Neto
contact affiliation	Butantan Institute
dataset submitter

Full Dataset Link List

jPOST dataset URI
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST003033/

jPOST dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST003033/