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PXD053987-1

PXD053987 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteomic analysis of two leukemia cell lines K562 and Lucena-1.
DescriptionThe Lucena 1 cell line, derived from the K562 human chronic myeloid leukemia cell line, shows multidrug resistance (MDR) due to selective pressure from vincristine supplementation. A proteomic analysis comparing K562 and Lucena 1 revealed qualitative differences. The ATP-dependent efflux pump, Translocase ABCB1, which is crucial for drug resistance, was a focus. Tubulin analysis identified an exclusive isoform, Tubulin beta 8B, in Lucena 1, potentially affecting resistance mechanisms. Additionally, Rap1A and Krit1 association in cytoskeletal regulation, along with STAT1 presence linked to urea cycle and tumor development, shed light on Lucena 1's unique biology. Increased Carbonic anhydrase I expression suggested a role in pH regulation. COP9, a tumor suppressor targeting p53, was discovered, further highlighting Lucena 1's complex molecular landscape. This study provides insights into the MDR phenotype and its multifactorial consequences in cellular pathways.
HostingRepositoryjPOST
AnnounceDate2024-08-13
AnnouncementXMLSubmission_2024-08-12_11:29:10.314.xml
DigitalObjectIdentifier
ReviewLevelNon peer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterEmidio Beraldo Neto
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListS-carboxamidomethyl-L-cysteine; L-methionine sulfoxide
Instrumentinstrument
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-07-16 10:18:33ID requested
12024-08-12 11:29:10announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: K562, Lucena-1, leukemia, MDR
Contact List
Emidio Beraldo Neto
lab head
Emidio Beraldo Neto
contact affiliationButantan Institute
dataset submitter
Full Dataset Link List
jPOST dataset URI
Dataset FTP location
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