PXD053934 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Identification of METTL3 succinylation sites |
| Description | The adaptation of tumor cells to metabolic stress is crucial for tumor development. We demonstrate that the translation of NRF2, a master regulator of antioxidant response, is controlled by the OGDH-METTL3 axis in melanoma for glucose starvation adaptation. To elucidate the regulatory mechanism of the OGDH-METTL3 axis during glucose starvation, we conducted co-immunoprecipitation and mass spectrometry analysis to identify the binding partner of OGDH that governs both the OGDH-METTL3 axis and tumor cell adaptation to glucose deprivation. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-06-30 |
| AnnouncementXML | Submission_2026-06-30_02:46:55.776.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Kejun Xu |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | succinylated residue |
| Instrument | 6520A Quadrupole Time-of-Flight LC/MS |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-07-13 23:21:45 | ID requested | |
| ⏵ 1 | 2026-06-30 02:46:56 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: succinylation,METTL3 |
Contact List
| Hang-zi Chen |
|---|
| contact affiliation | State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen 361102, Fujian Province, P. R. China |
| contact email | chenhz@xmu.edu.cn |
| lab head | |
| Kejun Xu |
|---|
| contact affiliation | Xiamen University |
| contact email | 1329490903@qq.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD053934
- Label: PRIDE project
- Name: Identification of METTL3 succinylation sites
