PXD053907 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Phospho-proteomic characterization of CCDC6-RET |
| Description | Here we show that a CCDC6-RET fusion product, a driver and therapeutic target in lung and thyroid cancers, is a highly active dimeric kinase in solution. Time-resolved mass spectrometry analysis together with a robust biochemical and biophysical characterization reveal the autophosphorylation kinetics and nucleotide dependency. Structural analyses together with cross-linking mass spectrometry data provided clear insights into the mechanism of autoactivation. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-04-27 |
| AnnouncementXML | Submission_2026-04-26_16:47:30.844.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Eduardo Zarzuela |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | phosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-07-12 01:52:05 | ID requested | |
| ⏵ 1 | 2026-04-26 16:47:31 | announced | |
Publication List
| Mart, í, n-Hurtado A, Contreras J, S, á, nchez-Wandelmer J, Zarzuela E, Garc, í, a F, Le Coq J, Boskovic J, Mu, ñ, oz IG, Gago F, Mu, ñ, oz J, Isasa M, Plaza-Menacho I, The oncogenic CCDC6-RET fusion protein is a dual ATP- and ADP-dependent kinase. Nat Commun, 17(1):(2026) [pubmed] |
| 10.1038/s41467-026-69833-y; |
Keyword List
| submitter keyword: CCDC6, phosphorylation, RET |
Contact List
| Marta Isasa |
|---|
| contact affiliation | CNIO |
| contact email | misasa@cnio.es |
| lab head | |
| Eduardo Zarzuela |
|---|
| contact affiliation | Centro Nacional de Investigaciones Oncológicas |
| contact email | eduzarfer@gmail.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD053907 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD053907
- Label: PRIDE project
- Name: Phospho-proteomic characterization of CCDC6-RET
