PXD053907

PXD053907 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Phospho-proteomic characterization of CCDC6-RET
Description	Here we show that a CCDC6-RET fusion product, a driver and therapeutic target in lung and thyroid cancers, is a highly active dimeric kinase in solution. Time-resolved mass spectrometry analysis together with a robust biochemical and biophysical characterization reveal the autophosphorylation kinetics and nucleotide dependency. Structural analyses together with cross-linking mass spectrometry data provided clear insights into the mechanism of autoactivation.
HostingRepository	PRIDE
AnnounceDate	2026-04-27
AnnouncementXML	Submission_2026-04-26_16:47:30.844.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Eduardo Zarzuela
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	phosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-07-12 01:52:05	ID requested
⏵ 1	2026-04-26 16:47:31	announced

Publication List

Mart, í, n-Hurtado A, Contreras J, S, á, nchez-Wandelmer J, Zarzuela E, Garc, í, a F, Le Coq J, Boskovic J, Mu, ñ, oz IG, Gago F, Mu, ñ, oz J, Isasa M, Plaza-Menacho I, The oncogenic CCDC6-RET fusion protein is a dual ATP- and ADP-dependent kinase. Nat Commun, 17(1):(2026) [pubmed]
10.1038/s41467-026-69833-y;

Mart, í, n-Hurtado A, Contreras J, S, á, nchez-Wandelmer J, Zarzuela E, Garc, í, a F, Le Coq J, Boskovic J, Mu, ñ, oz IG, Gago F, Mu, ñ, oz J, Isasa M, Plaza-Menacho I, The oncogenic CCDC6-RET fusion protein is a dual ATP- and ADP-dependent kinase. Nat Commun, 17(1):(2026) [pubmed]

10.1038/s41467-026-69833-y;

Keyword List

submitter keyword: CCDC6, phosphorylation, RET

submitter keyword: CCDC6, phosphorylation, RET

Contact List

Marta Isasa
contact affiliation	CNIO
contact email	misasa@cnio.es
lab head
Eduardo Zarzuela
contact affiliation	Centro Nacional de Investigaciones Oncológicas
contact email	eduzarfer@gmail.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD053907
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD053907

PRIDE project URI

Repository Record List

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