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PXD053906-1

PXD053906 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleIncreased viral tolerance mediates by antiviral RNA interference in bat cells
DescriptionBats harbor highly virulent viruses that can infect other mammals, including humans, posing questions about their immune tolerance mechanisms. Bat cells employ multiple strategies to limit virus replication and virus-induced immunopathology, but the coexistence of bats and fatal viruses remains poorly understood. Here, we investigated the antiviral RNA interference (RNAi) pathway in bat cells and discovered that they have an enhanced antiviral RNAi response, producing canonical viral small interfering RNAs (vsiRNAs) upon Sindbis virus (SINV) infection that were missing in human cells. Disruption of Dicer function resulted in increased viral load for three different RNA viruses in bat cells, indicating an interferon-independent antiviral pathway. Furthermore, our findings reveal the simultaneous engagement of Dicer and pattern-recognition receptors (PRRs), such as retinoic acid-inducible gene I (RIG-I), with double-stranded RNA, suggesting that Dicer attenuates the interferon response initiation in bat cells. These insights advance our comprehension of the distinctive strategies bats employ to coexist with viruses.
HostingRepositoryPRIDE
AnnounceDate2024-07-12
AnnouncementXMLSubmission_2024-07-12_02:59:56.327.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterYunpeng Dai
SpeciesList scientific name: Pteropus alecto (Black flying fox); NCBI TaxID: 9402;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-07-12 01:12:31ID requested
12024-07-12 02:59:56announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Pteropus alecto, SINV, dsRNA-IP, J2-IP
Contact List
Yang Li
contact affiliationState Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University
contact emailyangli15@fudan.edu.cn
lab head
Yunpeng Dai
contact affiliationFudan University
contact emailypdai20@fudan.edu.cn
dataset submitter
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Dataset FTP location
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