PXD053905 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteins binding in vitro to normal and mutant FMR1 5'UTR mRNA |
| Description | Expanded CGG repeats in the 5’UTR of fragile X messenger ribonucleoprotein 1 (FMR1) gene are translated to mutant protein containing polyglycine stretches (FMRpolyG), which evoke development of neurodegenerative disorder the fragile X-associated tremor/ataxia syndrome (FXTAS). However, little is known about the regulation of noncanonical translation of mutant FMR1 mRNA. Here, we show that insulin growth factor 2 binding proteins (IGF2BPs) directly bind to 5’UTR of FMR1 mRNA to selectively enhance biosynthesis of FMRpolyG. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-11-21 |
| AnnouncementXML | Submission_2025-11-21_05:09:00.054.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Anna Baud |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | iodoacetamide derivatized residue |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-07-11 23:34:55 | ID requested | |
| ⏵ 1 | 2025-11-21 05:09:00 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: FMR1,IGF2BP3, expanded CGG repeats, RNA pull down, RAN translation |
Contact List
| Krzysztof Sobczak |
|---|
| contact affiliation | Department of Gene Expression Institute of Molecular Biology and Biotechnology Faculty of Biology Adam Mickiewicz University Poland |
| contact email | krzysztof.sobczak@amu.edu.pl |
| lab head | |
| Anna Baud |
|---|
| contact affiliation | Adam Mickiewicz University in Poznan |
| contact email | annbau1@amu.edu.pl |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD053905
- Label: PRIDE project
- Name: Proteins binding in vitro to normal and mutant FMR1 5'UTR mRNA
