PXD053882-2

PXD053882 is an original dataset announced via ProteomeXchange.

Title	No evidence for the presence and control of tumor growth by stress granules in Kras mutant cancers
Description	Stress granules (SG) are membraneless ribonucleoprotein-based cytoplasmic organelles that assemble in response to stress. Their formation is often associated with an almost global suppression of translation. Consequently, the aberrant assembly or disassembly of these granules has pathological implications in neurodegeneration and cancer. In the latter situation, and particularly in the presence of mutations in the KRAS oncogene, in vivo studies have led to the idea that SG play an important role within cancer cells to increase their resistance to stress. Hence, SG have recently been considered as a promising new target for cancer therapy. In the present study, starting from an interest in G3BP1, a protein essential for the formation of SG, we came to look for the presence of SG during tumorigenesis. Through various experiments which combine in vitro, in vivo, and in silico approaches, performed both on mouse models and human samples and data, we reached the conclusion that SG are not present in KRAS-driven tumors, and therefore could not be considered as a valid therapeutic target for cancer treatment
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:59:51.146.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD053882
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Didier Vertommen
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2024-07-11 05:00:18	ID requested
1	2024-09-27 04:29:49	announced
⏵ 2	2024-10-22 06:59:51	announced	2024-10-22: Updated project metadata.

10.6019/PXD053882;

submitter keyword: cancer, stress granules,Kras

Dr Patrick Jacquemin
contact affiliation	Université catholique de Louvain, de Duve Institute, 1200 Brussels, Belgium
contact email	patrick.jacquemin@uclouvain.be
lab head
Didier Vertommen
contact affiliation	UCL - de Duve Institute, Brussels Belgium
contact email	didier.vertommen@uclouvain.be
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD053882
     1. Label: PRIDE project
     2. Name: No evidence for the presence and control of tumor growth by stress granules in Kras mutant cancers