PXD053818-2

PXD053818 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Low-input redoxomics facilitates global identification of metabolic regulators of oxidative stress in the gut
Description	we developed a low-input and user-friendly pipeline for the simultaneous profiling of five distinct Cys states with regional resolution in the gut of monkeys, including free SH, total Cys oxidation (Sto), sulfenic acid (SOH), S-nitrosylation (SNO), and S-glutathionylation (SSG), shedding light on redox modification stoichiometries and redox signaling of gut aging.Furthermore, redox-modification and proteomic analysis of colonic tissues of calorie-restricted aged mice revealed that CR can reduce oxidative stress and highlight the protective effect of CR on intestinal health.
HostingRepository	iProX
AnnounceDate	2024-12-16
AnnouncementXML	Submission_2025-12-16_01:19:48.723.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xina Xiao
SpeciesList	scientific name: Macaca fascicularis fascicularis; NCBI TaxID: 1215360; scientific name: Mus musculus; NCBI TaxID: 10090; scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	biotinyl-iodoacetamidyl-3,6-dioxaoctanediamine derivatized cysteine; phosphorylated residue
Instrument	Q Exactive Plus; Q Exactive HF

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-07-09 21:39:39	ID requested
1	2024-12-15 23:59:07	announced
⏵ 2	2025-12-16 01:19:49	announced	2025-12-16: Add info.

Publication List

Xiao X, Hu M, Gao L, Yuan H, Chong B, Liu Y, Zhang R, Gong Y, Du D, Zhang Y, Yang H, Liu X, Zhang Y, Zhang H, Xu H, Zhao Y, Meng W, Xie D, Lei P, Qi S, Peng Y, Tan T, Yu Y, Hu H, Dong B, Dai L, Low-input redoxomics facilitates global identification of metabolic regulators of oxidative stress in the gut. Signal Transduct Target Ther, 10(1):8(2025) [pubmed]

Xiao X, Hu M, Gao L, Yuan H, Chong B, Liu Y, Zhang R, Gong Y, Du D, Zhang Y, Yang H, Liu X, Zhang Y, Zhang H, Xu H, Zhao Y, Meng W, Xie D, Lei P, Qi S, Peng Y, Tan T, Yu Y, Hu H, Dong B, Dai L, Low-input redoxomics facilitates global identification of metabolic regulators of oxidative stress in the gut. Signal Transduct Target Ther, 10(1):8(2025) [pubmed]

Keyword List

submitter keyword: non-human primates, cysteine redox modification, gut aging, caloric restriction

submitter keyword: non-human primates, cysteine redox modification, gut aging, caloric restriction

Contact List

Lunzhi Dai
contact affiliation	Sichuan University
contact email	lunzhi.dai@scu.edu.cn
lab head
Xina Xiao
contact affiliation	Sichuan University
contact email	xina0xiao@163.com
dataset submitter

Full Dataset Link List

iProX dataset URI

iProX dataset URI