PXD053799-1

PXD053799 is an original dataset announced via ProteomeXchange.

Title	Control Of Major Bleeding After Trauma (COMBAT) Clinical Research Trial
Description	Denver Health has conducted the Control of Major Bleeding After Trauma (COMBAT) clinical research study, which aimed to improve trauma care for all patients (https://www.denverhealth.org/services/trauma/for-professionals-2/research-publications/combattrial). The study began in April 2014 and concluded in March of 2017. In collaboration with the University of Colorado Anschutz Medical Campus, longitudinal plasma samples collected from the COMBAT trial were analyzed by MS-based proteomics and metabolomics (available on Metabolomics Workbench).
HostingRepository	PRIDE
AnnounceDate	2025-08-29
AnnouncementXML	Submission_2025-08-29_00:01:28.874.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ian LaCroix
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2024-07-09 07:25:05	ID requested
⏵ 1	2025-08-29 00:01:30	announced

10.1016/j.bvth.2024.100017;

10.1016/s0140-6736(18)31553-8;

DeBot M, Erickson C, Schaid T, LaCroix I, Moore EE, Silliman C, Cohen MJ, D'Alessandro A, Hansen KC, Trauma-induced dysfibrinogenemia: the von Clauss assay does not accurately measure fibrinogen levels after injury. Blood Vessel Thromb Hemost, 1(3):100017(2024) [pubmed]

Pusateri AE, Moore EE, Moore HB, Le TD, Guyette FX, Chapman MP, Sauaia A, Ghasabyan A, Chandler J, McVaney K, Brown JB, Daley BJ, Miller RS, Harbrecht BG, Claridge JA, Phelan HA, Witham WR, Putnam AT, Sperry JL, Association of Prehospital Plasma Transfusion With Survival in Trauma Patients With Hemorrhagic Shock When Transport Times Are Longer Than 20 Minutes: A Post Hoc Analysis of the PAMPer and COMBAT Clinical Trials. JAMA Surg, 155(2):e195085(2020) [pubmed]

Moore HB, Moore EE, Chapman MP, McVaney K, Bryskiewicz G, Blechar R, Chin T, Burlew CC, Pieracci F, West FB, Fleming CD, Ghasabyan A, Chandler J, Silliman CC, Banerjee A, Sauaia A, Plasma-first resuscitation to treat haemorrhagic shock during emergency ground transportation in an urban area: a randomised trial. Lancet, 392(10144):283-291(2018) [pubmed]

10.1001/jamasurg.2019.5085;

submitter keyword: Trauma Patient Plasma

Kirk Hansen
contact affiliation	Department of Biochemistry and Molecular Genetics, University of Anschutz Medical Campus, Aurora CO
contact email	kirk.hansen@cuanschutz.edu
lab head
Ian LaCroix
contact affiliation	Graduate Student CU Anschutz Medical Campus
contact email	ian.lacroix@cuanschutz.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/08/PXD053799

PRIDE project URI

• PRIDE
  1. PXD053799
     1. Label: PRIDE project
     2. Name: Control Of Major Bleeding After Trauma (COMBAT) Clinical Research Trial