PXD053783-1

PXD053783 is an original dataset announced via ProteomeXchange.

Title	Influence of nutritionally physiological medium and 3D culture on breast cancer pharmacoproteomics
Description	Emerging evidence suggests that the nutrient availability in the tumour cell microenvironment and the dimensionality of in vitro tumour cells impact cell proteome and drug responsiveness. An improved physiological medium, called Melbourne Medium (MM), has been developed most recently by our research group. MM was designed to emulate low molecular weight components of human plasma, so it is a more physiologically relevant medium compared to conventional medium such as DMEM (CM). Global proteomics experiments were conducted to compare the protein profiles of MCF-7 and MDA-MB-231 breast cancer cells cultured in MM versus CM and in different experimental conditions (3D versus 2D).
HostingRepository	PRIDE
AnnounceDate	2024-11-30
AnnouncementXML	Submission_2024-11-30_06:50:13.059.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xiaodan Zhang
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2024-07-09 00:29:53	ID requested
⏵ 1	2024-11-30 06:50:13	announced

10.1016/J.PHRS.2024.107519;

submitter keyword: MDA-MB-231,breast cancer, physiological medium, 3D culture, MCF-7

Alastair Stewart
contact affiliation	Department of Biochemistry and Pharmacology, The University of Melbourne, VIC, Australia ARC Centre for Personalized Therapeutics Technologies, Melbourne, VIC, Australia
contact email	astew@unimelb.edu.au
lab head
Xiaodan Zhang
contact affiliation	The University of Melbourne
contact email	xiaodan2@student.unimelb.edu.au
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/11/PXD053783

PRIDE project URI

• PRIDE
  1. PXD053783
     1. Label: PRIDE project
     2. Name: Influence of nutritionally physiological medium and 3D culture on breast cancer pharmacoproteomics