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PXD053760-1

PXD053760 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleARL3 GTPases facilitate ODA16 unloading from IFT in motile cilia
DescriptionEukaryotic cilia and flagella are essential for cell motility and sensory functions. Their biogenesis and maintenance rely on the intraflagellar transport (IFT). Several cargo adapters have been identified to aid IFT cargo transport, but how ciliary cargos are discharged from IFT remains largely unknown. During our explorations of small GTPases ARL13 and ARL3 in Trypanosoma brucei, we found that ODA16, a known IFT cargo adapter found exclusively in motile cilia, is a specific effector of ARL3. To investigate how TbARL3A and TbARL3C regulate TbODA16, we performed proximity-dependent biotin identification (BioID) and mass spectrometry analyses for TbODA16 in the presence or absence of TbARL3A and TbARL3C.
HostingRepositoryPRIDE
AnnounceDate2024-09-05
AnnouncementXMLSubmission_2024-09-04_20:18:12.163.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterYameng Huang
SpeciesList scientific name: Trypanosoma brucei; NCBI TaxID: 5691;
ModificationListbiotinylated residue
InstrumentTripleTOF 5600
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-07-08 08:08:41ID requested
12024-09-04 20:18:12announced
Publication List
10.1126/SCIADV.ADQ2950;
Keyword List
submitter keyword: TbODA16 BioID2
Contact List
Cynthia Y. He
contact affiliationDepartment of Biological Sciences, National University of Singapore
contact emaildbshyc@nus.edu.sg
lab head
Yameng Huang
contact affiliationDepartment of Biological Sciences, National University of Singapore
contact emailyameng.h@nus.edu.sg
dataset submitter
Full Dataset Link List
Dataset FTP location
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