PXD053732-1
PXD053732 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | LC-MS/MS analysis of conditioned medium from primary breast cancer cells (PBCs#2/#3/#5) and bone-metastatic breast cancer cells (BMBCs#2/#3/#5) |
Description | Bone is the most common metastasis site in patients with breast cancer, and approximately up to 80% of patients with advanced breast cancer (BC) develop bone metastasis (BM), which leads to a worse prognosis with a median survival of 16 months and skeletal-related events (SREs), including severe bone pain, pathological fracture, hypercalcemia and lethal complications. Using quantitative proteomics mass-spectrometry (MS) analysis of the secretome from patient-derived primary BC cells (PBCs) and bone-metastatic BC cells (BMBCs), we identified an unreported breast cancer (BC) cells–secreted microprotein, osteolysin, encoded by tropomyosin 3 pseudogene 9 (TPM3P9) and clinically associated with BC bone-tropism. |
HostingRepository | iProX |
AnnounceDate | 2024-07-05 |
AnnouncementXML | Submission_2024-07-08_02:00:52.212.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Shuxia Zhang |
SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2024-07-07 20:45:09 | ID requested | |
⏵ 1 | 2024-07-08 02:00:52 | announced |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Human, breast cancer, LC-MS/MS |
Contact List
Jun Li | |
---|---|
contact affiliation | Sun Yat-sen University |
contact email | zhangshx29@mail.sysu.edu.cn |
lab head | |
Shuxia Zhang | |
contact affiliation | Sun Yat-sen University |
contact email | zhangshx8@mail2.sysu.edu.cn |
dataset submitter |
Full Dataset Link List
iProX dataset URI |