PXD053689-1
PXD053689 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Multi-Omics Analysis Unveils Nsun5-Mediated Molecular Alterations in the Somatosensory Cortex and its Impact on Pain Sensation |
| Description | Nsun5 assumes a pivotal role in the regulation of RNA methylation, and its deficiency has been linked to the advancement of hepatocellular carcinoma, gliomas, tetralogy of Fallot, cognitive deficits in Williams–Beuren syndrome (WBS), and brain development. This underscores Nsun5's significant involvement in the nervous system. In this study, we present evidence of Nsun5's influence on the structure of the primary somatosensory cortex. Through comprehensive multi-omics analyses, we unveil a spectrum of systematically altered genes and proteins, collectively engaged in the orchestration of translation, neurotransmitter metabolism, nerve conduction, synaptic transmission, and other functions. Notably, there are discernible changes in molecules associated with pain sensation, strongly indicating that Nsun5 deficiency undermines pain-related behavior. This investigation establishes a clear link between Nsun5 deficiency and molecular as well as morphological transformations within the primary somatosensory cortex, thereby confirming its role in impairing pain sensation. |
| HostingRepository | iProX |
| AnnounceDate | 2024-07-05 |
| AnnouncementXML | Submission_2024-07-05_02:58:04.880.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Peipei Chen |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-07-05 02:57:17 | ID requested | |
| ⏵ 1 | 2024-07-05 02:58:05 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Nsun5, multi-omics analyses, primary somatosensory cortex, pain sensation |
Contact List
| Huali Shen | |
|---|---|
| contact affiliation | Fudan Universtiy |
| contact email | shenhuali@fudan.edu.cn |
| lab head | |
| Peipei Chen | |
| contact affiliation | Fudan University |
| contact email | chen930513@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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