PXD053645 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Co-IP protein identification of WT/MT IVNS1ABP in isogenic iPSCs derived NPCs |
| Description | We identified a new disease characterized by severe neurological deficits in addition to progeria symptoms. It is caused by IVNSABP gene mutation. The association between IVNS1ABP and aging has never been reported before. By generating isogenic iPSCs from the patients’ fibroblasts and differentiating the iPSCs into neural progenitor cells (NPCs),we performed a pull-down assay with an IVNS1ABP antibody, followed by mass spectrometry to identify the potential protein interactors of both wild type (Ctrl) and MT IVNS1ABP using NPCs from the isogenic pairs. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-01-23 |
| AnnouncementXML | Submission_2026-01-23_14:16:48.863.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Fang YUAN |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | LTQ Orbitrap Elite |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-07-04 09:52:32 | ID requested | |
| ⏵ 1 | 2026-01-23 14:16:49 | announced | |
Publication List
Keyword List
| submitter keyword: iPSCs, NPCs, Co-IP, IVNS1ABP |
Contact List
| Su-Chun Zhang |
|---|
| contact affiliation | Duke-NUS Medical School, Singapore. Department of Neuroscience, Department of Neurology, School of Medicine and Public Health, Waisman Center, University of Wisconsin, USA. |
| contact email | su-chun.zhang@duke-nus.edu.sg |
| lab head | |
| Fang YUAN |
|---|
| contact affiliation | Duke-NUS Medical School |
| contact email | yuanfang@duke-nus.edu.sg |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/01/PXD053645 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD053645
- Label: PRIDE project
- Name: Co-IP protein identification of WT/MT IVNS1ABP in isogenic iPSCs derived NPCs
