PXD053633-1

PXD053633 is an original dataset announced via ProteomeXchange.

Title	In vivo fitness of sul gene-dependent sulfonamide-resistant Escherichia coli in the mammalian gut
Description	Sulfonamides are traditional synthetic antimicrobial agents used in clinical and veterinary medical settings. Their long-term excessive overuse has resulted in widespread microbial resistance, limiting their application for medical interventions. Resistance to sulfonamides is primarily conferred by the alternative genes sul1, sul2, and sul3 encoding dihydropteroate synthase in bacteria. Studying the potential fitness cost of these sul genes is crucial for understanding the evolution and transmission of sulfonamide-resistant bacteria. In vitro studies have been conducted on the fitness cost of sul genes in bacteria. In this study, we provide critical insights into bacterial adaptation and transmission using an in vivo approach.
HostingRepository	iProX
AnnounceDate	2024-07-04
AnnouncementXML	Submission_2024-07-03_23:49:42.941.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jiehong Fang
SpeciesList	scientific name: Escherichia coli str. K-12 substr. MG1655; NCBI TaxID: 511145;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2024-07-03 23:48:36	ID requested
⏵ 1	2024-07-03 23:49:43	announced

Dataset with its publication pending

submitter keyword: Sulfonamide resistance gene, Fitness cost, In vivo, Quantitative proteomic method, E. coli

Jiehong Fang
contact affiliation	China Jiliang University
contact email	fangjh@cjlu.edu.cn
lab head
Jiehong Fang
contact affiliation	China Jiliang University
contact email	fangjh@cjlu.edu.cn
dataset submitter

iProX dataset URI