PXD053590 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Analysis of C. elegans DAF-16 phosphorylation in different genetic backgrounds. |
| Description | C. elegans DAF-16/FOXO phosphorylation in different genetic backgrounds was analyzed by mass spectrometry of affinity purified HA-tagged DAF-16. Genetic backgrounds studied include par-1 hypomorphic mutants, PAR-1 knockdown using an auxin-inducible degron (AID), daf-2(e1370) and akt-1(ok525) mutants. PAR-1 is the C. elegans ortholog of MARK kinases; DAF-2 is the sole C. elegans insulin/IGF receptor, and AKT-1 is one of two AKT kinases in the nematode. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-12-29 |
| AnnouncementXML | Submission_2025-12-28_16:17:56.943.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Markus Hartl |
| SpeciesList | scientific name: Caenorhabditis elegans; NCBI TaxID: NEWT:6239; |
| ModificationList | phosphorylated residue |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-07-03 00:18:55 | ID requested | |
| ⏵ 1 | 2025-12-28 16:17:57 | announced | |
Publication List
| 10.1038/s41467-025-66409-0; |
| Artan M, Schoen H, de Bono M, Proximity labeling of DAF-16 FOXO highlights aging regulatory proteins. Nat Commun, 16(1):11355(2025) [pubmed] |
Keyword List
| submitter keyword: FOXO, PAR-1,DAF-16, phosphorylation, DAF-2, MARK, AKT-1 |
Contact List
| Mario de Bono |
|---|
| contact affiliation | Institute of Science and Technology Austria (ISTA) |
| contact email | Mario.deBono@ist.ac.at |
| lab head | |
| Markus Hartl |
|---|
| contact affiliation | Max Perutz Labs, Mass Spectrometry Facility, Vienna Biocenter Campus (VBC), Dr. Bohr-Gasse 9, Vienna, Austria |
| contact email | proteomics@maxperutzlabs.ac.at |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/12/PXD053590 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD053590
- Label: PRIDE project
- Name: Analysis of C. elegans DAF-16 phosphorylation in different genetic backgrounds.
