PXD053545-1
PXD053545 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Thiol redox proteomic changes in Jurkat cells resulting from knockout of peroxiredoxin 1 or peroxiredoxin 2 |
Description | Peroxiredoxins are thiol proteins involved in antioxidant defense and redox signaling. One putative signaling mechanism involves the facilitated oxidation of associated proteins via a redox relay. We have investigated if removal of the cytoplasmic peroxiredoxins Prdx1 and Prdx2 influences the redox state of other thiol proteins in cultured cells. A mass spectrometric proteomic approach in which reduced thiols in one cell type were labelled with a heavy isotope tag and reduced thiols in the other cell type with a light isotope tag, was used to compare wild type (WT) Jurkat cells with cells in which either Prdx1 or Prdx2 was knocked out (KO). |
HostingRepository | iProX |
AnnounceDate | 2024-07-02 |
AnnouncementXML | Submission_2024-07-01_21:12:33.130.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Ling Fu |
SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
ModificationList | (13)C labeled residue |
Instrument | Q Exactive HF-X |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2024-07-01 21:11:27 | ID requested | |
⏵ 1 | 2024-07-01 21:12:33 | announced |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Thiol redox proteomic |
Contact List
Jing Yang | |
---|---|
contact affiliation | National Center for Protein Sciences (PHOENIX, Beijing) |
contact email | yangjing54@hotmail.com |
lab head | |
Ling Fu | |
contact affiliation | National Center for Protein Sciences (PHOENIX, Beijing) |
contact email | flsmt@163.com |
dataset submitter |
Full Dataset Link List
iProX dataset URI |