PXD053438 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | HeLa Pro-IL-1a TurboID LC-MS/MS |
| Description | Pro-IL-1a is a pro-inflammatory cytokine that is localised to the nucleus in humans due to the presence of a nuclear localisation sequence in its pro-domain. However, some mammals have a predicted loss of fucntion to their nuclear localistion sequence. It is suggested that pro-IL-1a serves as a dual action protein, and that in addition to its role as a cytokine, it has an additional nuclear role. Therefore, we used biotin proximity labelling to explore the protein interactome of pro-IL-1a with the aim to investogate possible additional roles of this protein. We have suggested in our study that interaction with histone acetyl trasnferases may suggest a possible nuclear function of pro-IL-1a. |
| HostingRepository | PRIDE |
| AnnounceDate | 2024-10-22 |
| AnnouncementXML | Submission_2024-10-22_06:47:49.972.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Rose Wellens |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
| ModificationList | biotinylated residue |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-06-26 13:20:30 | ID requested | |
| 1 | 2024-06-28 06:33:30 | announced | |
| 2 | 2024-08-19 05:00:43 | announced | 2024-08-19: Updated project metadata. |
| ⏵ 3 | 2024-10-22 06:47:50 | announced | 2024-10-22: Updated project metadata. |
Publication List
| 10.1038/s41467-024-50901-0; |
| Wellens R, Tapia VS, Seoane PI, Bennett H, Adamson A, Coutts G, Rivers-Auty J, Lowe M, Green JP, Lopez-Castejon G, Brough D, Hoyle C, reveals evolutionary conserved nuclear interactions. Nat Commun, 15(1):6750(2024) [pubmed] |
Keyword List
| submitter keyword: inflammation, TurboID, biotin ligase proximity labelling,Pro-Interleukin-1 alpha, histone acetyl transferase, LC-MS/MS |
Contact List
| David Brough |
|---|
| contact affiliation | Division of Neuroscience, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, M13 9PT, UK. Geoffrey Jefferson Brain Research Centre, The Manchester Academic Health Science Centre, Northern Care Alliance NHS Group, University of Manchester, Manchester, M13 9PT, UK. The Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, M13 9PT, UK. |
| contact email | david.brough@manchester.ac.uk |
| lab head | |
| Rose Wellens |
|---|
| contact affiliation | University of Manchester |
| contact email | rose.a.wellens@gmail.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/06/PXD053438 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD053438
- Label: PRIDE project
- Name: HeLa Pro-IL-1a TurboID LC-MS/MS
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