PXD053372-1

PXD053372 is an original dataset announced via ProteomeXchange.

Title	ASC and SAA protein interaction profiling by limited proteolysis coupled to mass spectrometry
Description	Upon activation of ASC-containing inflammasomes, intracellular molecular aggregates (ASC specks) are assembled and released from myeloid cells into the extracellular space where they enhance the aggregation of Aβ amyloid in Alzheimer’s disease. This raises the question whether ASC is involved in additional aggregation proteinopathies. In this study we report that ASC governs the extent of inflammation-induced amyloid A (AA) amyloidosis, a systemic disease caused by the aggregation and peripheral deposition of the acute-phase reactant serum amyloid A (SAA).
HostingRepository	PRIDE
AnnounceDate	2025-05-07
AnnouncementXML	Submission_2025-05-06_20:46:17.461.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Tetiana Serdiuk
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2024-06-24 13:47:57	ID requested
⏵ 1	2025-05-06 20:46:18	announced

Losa M, Emmenegger M, De Rossi P, Sch, ü, rch PM, Serdiuk T, Pengo N, Capron D, Bieli D, Bargenda N, Rupp NJ, Carta MC, Frontzek KJ, Lysenko V, Reimann RR, Schwarz P, Nuvolone M, Westermark GT, Nilsson KPR, Polymenidou M, Theocharides AP, Hornemann S, Picotti P, Aguzzi A, The ASC inflammasome adapter governs SAA-derived protein aggregation in inflammatory amyloidosis. EMBO Mol Med, 16(9):2024-2042(2024) [pubmed]

10.1038/s44321-024-00107-0;

submitter keyword: inflamation, SAA,LiP-MS, ASC

Paola Picotti
contact affiliation	Institute of Molecular Systems Biology, Department of Biology, ETH Zurich
contact email	picotti@imsb.biol.ethz.ch
lab head
Tetiana Serdiuk
contact affiliation	Institute of Molecular Systems Biology, ETH Zurich, Switzerland
contact email	tserdiuk@ethz.ch
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD053372

PRIDE project URI

• PRIDE
  1. PXD053372
     1. Label: PRIDE project
     2. Name: ASC and SAA protein interaction profiling by limited proteolysis coupled to mass spectrometry