PXD053362-1

PXD053362 is an original dataset announced via ProteomeXchange.

Title	Proteomic profiling of kidney biopsies in nephrotic syndrome
Description	Minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS) are patterns of kidney injury observed in the filtering units of the kidney known as glomeruli. From the NURTuRE cohort of individuals with nephrotic syndrome (NS), we performed laser microdissection and mass spectrometry analysis of kidney biopsy samples to identify proteomic patterns of disease. 56 individuals with idiopathic NS segregated by histological pattern (37 MCD and 19 FSGS) across three age groups: early childhood (0-6 years), late childhood (6-18 years) and adult (>18 years). We identified global differences in glomerular cell and extracellular matrix composition related to both histological pattern and age.
HostingRepository	PRIDE
AnnounceDate	2024-07-15
AnnouncementXML	Submission_2024-07-15_01:55:51.607.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Anna S Li
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2024-06-24 09:22:13	ID requested
⏵ 1	2024-07-15 01:55:51	announced
2	2024-10-22 06:49:49	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: NURTuRE cohort, Laser-microdissection, Global proteomics, Minimal change, Focal segmental glomerulosclerosis, Nephrotic syndrome

Rachel Lennon
contact affiliation	Division of Cell Matrix Biology and Regenerative Medicine School of Biological Sciences Faculty of Biology, Medical and Health Sciences University of Manchester
contact email	rachel.lennon@manchester.ac.uk
lab head
Anna S Li
contact affiliation	University of Manchester
contact email	shanshan.li@manchester.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/07/PXD053362

PRIDE project URI

• PRIDE
  1. PXD053362
     1. Label: PRIDE project
     2. Name: Proteomic profiling of kidney biopsies in nephrotic syndrome