PXD053336-1
PXD053336 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | A chemical screen identifies PRMT5 as a therapeutic vulnerability for paclitaxel-resistant triple-negative breast cancer |
| Description | Through chemical probe screening, we uncovered a novel mechanism of RNA splicing in paclitaxel-resistant TNBC and identified PRMTs as therapeutic targets. |
| HostingRepository | iProX |
| AnnounceDate | 2024-06-22 |
| AnnouncementXML | Submission_2024-06-24_00:07:12.964.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Sheyu Zhang |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-06-24 00:06:12 | ID requested | |
| ⏵ 1 | 2024-06-24 00:07:13 | announced | |
| 2 | 2024-12-12 19:09:00 | announced | 2024-12-13: Update information. |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: TNBC, paclitaxel-resistant , PRMT5, RNA-splicing, AURKB, mitosis |
Contact List
| Qin Wu | |
|---|---|
| contact affiliation | Hangzhou Instititute of Medicine |
| contact email | wuqin@ibmc.ac.cn |
| lab head | |
| Sheyu Zhang | |
| contact affiliation | Hangzhou Instititute of Medicine |
| contact email | 2020213009@tju.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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