PXD053332-1

PXD053332 is an original dataset announced via ProteomeXchange.

Title	Leflunomide Alleviates Nonmotor Symptoms in Myasthenia Gravis by Modulating Brain Metabolic Pathways via PKCγ in EAMG Lewis Rats
Description	Myasthenia gravis (MG) is a rare autoimmune disorder traditionally characterized by motor symptoms, while nonmotor symptoms like anxiety, insomnia, and memory impairment have received less attention due to the complexities of brain-related studies. Leflunomide (LEF), a frontline medication for rheumatoid arthritis, has shown high efficacy in treating both motor and nonmotor symptoms of MG in our decade-long clinical research. This study aimed to explore the therapeutic mechanisms of LEF, particularly its metabolites' actions in the brain. We employed spatial metabolomics (SM) and 4D-DIA proteomics to identify LEF's key active metabolite. These metabolites play pivotal roles in constructing the metabolic pathway maps that support LEF's mechanism of action. We aimed to find the key protein affecting MG's nonmotor symptoms.
HostingRepository	iProX
AnnounceDate	2024-06-22
AnnouncementXML	Submission_2026-01-04_00:18:03.062.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Hao Ran
SpeciesList	scientific name: Rattus norvegicus; NCBI TaxID: 10116;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2024-06-23 23:58:40	ID requested
⏵ 1	2026-01-04 00:18:03	announced

Dataset with its publication pending

submitter keyword: Myasthenia gravis, timsTOF Pro2, 4D-DIA, 4D-PRM, LC-MS/MS

Weibin Liu
contact affiliation	The First Affiliated Hospital of Sun Yat sen University
contact email	liuwb@mail.sysu.edu.cn
lab head
Hao Ran
contact affiliation	Sun Yat-sen University
contact email	ranhao@mail.sysu.edu.cn
dataset submitter

iProX dataset URI