PXD053305-1

PXD053305 is an original dataset announced via ProteomeXchange.

Title	The Tel1 Phosphoproteomic Network
Description	Large-scale unbiased phosphoproteomics analysis of Tel1-deleted yeast reveal dozens of novel Tel1-dependent phosphorylation events. The canonical S/T-Q motif is enriched amongst these Tel1-dependent sites, but a novel D/E-S/T motif is even more highly enriched. Phosphoproteomics of possible downstream acidophilic kinases Dun1, Rad53, and Hrr25 are performed to determine if these sites may be indirectly Tel1-dependent, but the D/E-S/T sites are not dependent on any of them.
HostingRepository	PRIDE
AnnounceDate	2025-05-07
AnnouncementXML	Submission_2025-05-06_21:39:49.420.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	William Comstock
SpeciesList	scientific name: Saccharomyces cerevisiae (Baker's yeast); NCBI TaxID: 4932;
ModificationList	6x(13)C; 6x(13)C; phosphorylated residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2024-06-22 10:59:08	ID requested
⏵ 1	2025-05-06 21:39:50	announced

Comstock WJ, Bhattarai S, Sanford EJ, Navarro MVAS, Smolka MB, Profiling Tel1 signaling reveals a non-canonical motif targeting DNA repair and telomere control machineries. J Biol Chem, 301(3):108194(2025) [pubmed]

10.1016/j.jbc.2025.108194;

submitter keyword: Tel1 Phosphoproteomics Phosphorylation DNA damage signaling network genome maintenance

Marcus Smolka
contact affiliation	Cornell University
contact email	mbs266@cornell.edu
lab head
William Comstock
contact affiliation	Cornell University
contact email	wc622@cornell.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD053305

PRIDE project URI

• PRIDE
  1. PXD053305
     1. Label: PRIDE project
     2. Name: The Tel1 Phosphoproteomic Network