PXD053298-1

PXD053298 is an original dataset announced via ProteomeXchange.

Title	Bleomycin and methotrexate-induced pulmonary toxicity in human LC-MSMS
Description	Drug-induced lung injury rarely, but seriously leads to severe lung diseases such as interstitial pneumonia and pulmonary fibrosis. However, the mechanism underlying drug-induced lung injury remains unclear. Anticancer drugs frequently induce pulmonary damage compared to the other categories of the drugs. In this study, the effect of bleomycin and methotrexate, which are representative pulmonary toxic anticancer drugs, on the comprehensive protein expression levels in alveolar epithelial model cell line, A549.
HostingRepository	PRIDE
AnnounceDate	2025-07-25
AnnouncementXML	Submission_2025-07-25_07:12:42.255.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Masashi Kawami
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	ZenoTOF 7600

Revision	Datetime	Status	ChangeLog Entry
0	2024-06-22 01:34:01	ID requested
⏵ 1	2025-07-25 07:12:42	announced

10.1016/J.BBAGEN.2024.130746;

submitter keyword: epithelium, LC-MSMS, alveolus, methotrexate,Cell lines, A549, bleomycin

Yasuo Uchida
contact affiliation	Department of Molecular Systems Pharmaceutics, Biomedical and Health Sciences, Hiroshima University
contact email	yuchida@hiroshima-u.ac.jp
lab head
Masashi Kawami
contact affiliation	Mukogawa Women's University
contact email	kawami_masashi_x@mukogawa-u.ac.jp
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/07/PXD053298

PRIDE project URI

• PRIDE
  1. PXD053298
     1. Label: PRIDE project
     2. Name: Bleomycin and methotrexate-induced pulmonary toxicity in human LC-MSMS