PXD053287-1

PXD053287 is an original dataset announced via ProteomeXchange.

Title	The Detection of Heat Stress by Assessing individual Body Responses to Heat (Heat Strain) in Young and Healthy Non-athlete Participants
Description	Heat stress can reduce work performance and increases the risk for work related injuries. An in-depth understanding of the molecular heat strain signature in sweat for an extended personalized molecular monitoring is lacking. The HEATSTAR project is, to the best of our knowledge, the first project to use a personalized study setting to assess the molecular signature of proteomics and metabolomics in sweat during moderate heat stress. It was investigated if biomarker candidates can be identified that allow us to differentiate between various heat stressors. For this, we conducted a personalized, cross-sectional, crossover pilot trial with randomized study visits. Healthy non-athlete participants aged 18-40 were included and four different types of heat stressors applied. The local sweat rate through technical absorbents, the whole body sweat rate, and sweat’s metabolomic as well as proteomic molecular composition were assessed.
HostingRepository	PRIDE
AnnounceDate	2025-04-04
AnnouncementXML	Submission_2025-04-04_12:10:16.390.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Noé Brasier
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2024-06-21 13:09:06	ID requested
⏵ 1	2025-04-04 12:10:16	announced

Dataset with its publication pending

submitter keyword: HEATSTAR,heat stress, sweat,proteomic and metabolommic signature, timsTOF Pro

Noé Brasier
contact affiliation	Institute of Translational Medicine, Department Health Science and Technology, ETH Zurich, Zurich, Switzerland
contact email	nbrasier@ethz.ch
lab head
Noé Brasier
contact affiliation	ETH Zurich
contact email	nbrasier@ethz.ch
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/04/PXD053287

PRIDE project URI

• PRIDE
  1. PXD053287
     1. Label: PRIDE project
     2. Name: The Detection of Heat Stress by Assessing individual Body Responses to Heat (Heat Strain) in Young and Healthy Non-athlete Participants