PXD053279 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | The adhesion RadD enhances Fusobacterium nucleatum tumor colonization and colorectal carinogenesis |
Description | Fusobacterium nucleatum can bind to host cells and potentiate intestinal tumorigenesis. Here, we used a genome-wide screen to identify an adhesin, RadD, which facilitates the attachment of F. nucleatum to CRC cells in vitro. RadD directly binds to CD147, a receptor overexpressed on CRC cell surfaces, which initiated a PI3K-AKT-NF-kB-MMP9 cascade, subsequently enhanceing tumorigenesis in mice. Clinical specimen analysis showed that elevated radD levels in CRC tissues correlated positively with activated oncogenic signaling and poor patient outcomes. Finally, blockade of the interaction between RadD and CD147 in mice effectively impaired F. nucleatum attachment and attenuated F. nucleatum-induced oncogenic response. Together, our study provides insights into an oncogenic mechanism driven by F. nucleatum RadD and suggests taht the RadD-CD147 interaction could be a potential therapeutic target for CRC. |
HostingRepository | PRIDE |
AnnounceDate | 2024-07-10 |
AnnouncementXML | Submission_2024-07-09_17:25:41.656.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Lu Zhang |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2024-06-21 06:05:21 | ID requested | |
⏵ 1 | 2024-07-09 17:25:42 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: F. nucleatum RadD, CD147 receptor, colorectal cancer |
Contact List
Lu Zhang |
contact affiliation | Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China |
contact email | zhanglu02@sibs.ac.cn |
lab head | |
Lu Zhang |
contact affiliation | Renji Hospital, School of Medicine, Shanghai Jiao Tong University |
contact email | zhangluxc@163.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD053279
- Label: PRIDE project
- Name: The adhesion RadD enhances Fusobacterium nucleatum tumor colonization and colorectal carinogenesis