PXD053278-1

PXD053278 is an original dataset announced via ProteomeXchange.

Title	Proteome selectivity profiling of photoaffinity probes derived from imidazopyrazine-kinase inhibitors
Description	Kinases are attractive drug targets, but the design of highly selective kinase inhibitors remains challenging. Selectivity may be evaluated against a panel of kinases, or – preferred – in a complex proteome. Probes that allow photoaffinity-labeling of their targets can facilitate this process. Here, we report photoaffinity probes based on the imidazopyrazine scaffold, which is found in several kinase inhibitors and drugs or drug candidates. By chemical proteomics experiments, we find a range of off-targets, which vary between the different probes.
HostingRepository	PRIDE
AnnounceDate	2024-10-28
AnnouncementXML	Submission_2024-10-28_08:25:27.315.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Steven Verhelst
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2024-06-21 03:43:58	ID requested
⏵ 1	2024-10-28 08:25:27	announced

10.26434/CHEMRXIV-2024-FNPC7;

submitter keyword: kinase inhibitors, imidazopyrazines,photoaffinity labeling

Steven Verhelst
contact affiliation	KU Leuven – University of Leuven, Laboratory of Chemical Biology, Department of Cellular and Molecular Medicine, Herestraat 49 box 901b, 3000 Leuven, Belgium
contact email	steven.verhelst@kuleuven.be
lab head
Steven Verhelst
contact affiliation	KU Leuven
contact email	steven.verhelst@kuleuven.be
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/10/PXD053278

PRIDE project URI

• PRIDE
  1. PXD053278
     1. Label: PRIDE project
     2. Name: Proteome selectivity profiling of photoaffinity probes derived from imidazopyrazine-kinase inhibitors