⮝ Full datasets listing
PXD053267-1
PXD053267 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | SIX1 drives endothelial dysfunction via MAST4/MAPK 1/3 axis to promote pulmonary artery hypertension |
| Description | Increasing evidences support that endothelial dysfunction initiates and drives pulmonary vascular remodeling. Targeting endothelial dysfunction is a promising treatment strategy for pulmonary artery hypertension (PAH). Therefore, it is urgent to elucidate the pathological mechanism of endothelial dysfunction. SIX1 is a critical transcription factor that regulates pulmonary vascular development. Lack of SIX1 impairs the differentiation of pulmonary vascular endothelial cells into smooth muscle cells. However, the role of SIX1 in endothelial dysfunction and PAH is unknown. In this study, we confimed that SIX1 was a critical transicription factor to induced endothelial dysfunction and PAH, and uncoverd that MAST4 was the target of SIX1-mediating endothelial dysfunction. MAST4 is a serine/threonine kinase, however the underlying mechanism by which MAST4 mediated endothelial dysfunction was unknown. Therefore, we planed to perform phosphoproteomics to explore the underlying mechanism. |
| HostingRepository | iProX |
| AnnounceDate | 2024-06-20 |
| AnnouncementXML | Submission_2025-12-15_18:52:18.042.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Ting Liu |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-06-20 21:46:23 | ID requested | |
| ⏵ 1 | 2025-12-15 18:52:18 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: SIX1, endothelial dysfunction, MAST4, MPAK1/3, pulmonary artery hypertension, Zafirlukast |
Contact List
| Ting Liu | |
|---|---|
| contact affiliation | Zhejiang Provincial People’s Hospital |
| contact email | 514634498@qq.com |
| lab head | |
| Ting Liu | |
| contact affiliation | Zhejiang Provincial People’s Hospital |
| contact email | 514634498@qq.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
