PXD053264 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | The nuclear export protein XPO1 provides a peptide ligand for natural killer cells |
Description | XPO1 is a nuclear export protein that is frequently overexpressed in cancer and functions as a driver of oncogenesis. Currently small molecules that target XPO1 are being used in the clinic as anti-cancer agents. We identify XPO1 as a target for natural killer (NK) cells. Using immunopeptidomics we have identified a peptide derived from XPO1 that can be recognized by the activating NK cell receptor KIR2DS2 in the context of HLA-C. The peptide can be endogenously processed and presented to activate NK cells specifically through this receptor. Although high XPO1 expression in cancer is commonly associated with a poor prognosis, we show that the outcome of specific cancers, such as hepatocellular carcinoma, can be substantially improved if there is concomitant evidence of NK cell infiltration. We thus identify XPO1 as a bona fide tumor antigen recognised by NK cells, that offers an opportunity for a personalized approach to NK cell therapy for solid tumors. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-17 |
AnnouncementXML | Submission_2024-10-17_02:45:00.744.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Ralf Schittenhelm |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive; Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2024-06-20 19:24:58 | ID requested | |
⏵ 1 | 2024-10-17 02:45:01 | announced | |
Publication List
10.1126/sciadv.ado6566; |
Blunt MD, Fisher H, Schittenhelm RB, Mbiribindi B, Fulton R, Khan S, Espana-Serrano L, Graham LV, Bastidas-Legarda L, Burns D, Khakoo SMS, Mansour S, Essex JW, Ayala R, Das J, Purcell AW, Khakoo SI, The nuclear export protein XPO1 provides a peptide ligand for natural killer cells. Sci Adv, 10(34):eado6566(2024) [pubmed] |
Keyword List
submitter keyword: natural killer cells, KIR2DS2, HLA-C*0102, HUH7 cells,hepatocellular carcinoma |
Contact List
Salim Khakoo |
contact affiliation | University of Southampton, Southampton, UK |
contact email | s.i.khakoo@soton.ac.uk |
lab head | |
Ralf Schittenhelm |
contact affiliation | Monash University |
contact email | ralf.schittenhelm@monash.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD053264
- Label: PRIDE project
- Name: The nuclear export protein XPO1 provides a peptide ligand for natural killer cells